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beryllium flouride is an inorganic compound whose formula is BeF2. It is a hygroscopic, white solid that melts at 800 degC. It is used as a precursor in the manufacture of beryllium metal and glass and in nuclear reactors.
In its pure form, it has a silica-like structure with beryllium in four-coordinate positions and fluoride in two-coordinate positions. It has a refractive index of 1.275 and a dispersive power of 0.0093 at room temperature.
It is also a very useful tool in biochemistry, where it is used as a mimic of phosphate in protein crystallography. When applied to a GroEL mutant that lacks ATP hydrolysis, or in the presence of ADP-metal complexes, BeF3- and A1F3 mimic the large rigid body domain movements associated with ejection of polypeptide into the central cavity (Denny and Sondermann, unpublished data).
The 9Be NMR parameters of beryllium fluoride complexes formed in aqueous solutions are sensitive markers of anisotropic molecular environments produced by gelatin gels. The uniformly anisotropic media afforded by these gels are being increasingly exploited in analytical (structure elucidation) nuclear magnetic resonance (NMR) spectroscopy, and in studies of mechanosensitive biophysical and biochemical properties of living cells.
Inhalation of beryllium fluoride fumes may lead to acute respiratory distress, coughing, laboured breathing, and shortness of breath. This may be followed by a pulmonary lesion. Other symptoms are headache, dizziness and nausea. In a few cases, conjunctivitis has been reported. These symptoms may persist for a short time after inhalation of fumes.