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silica gel molecular weight is an amorphous silica compound with the formula SiO2. It has a porous structure that is naturally able to absorb water and other liquids. This characteristic makes silica gel an excellent moisture indicator and desiccant. Silica gel is commonly seen in sachets in new bottles of medications and vitamins, camera and cell phone boxes to prevent mold, in paper-based collectibles such as comics and football cards, and museum display cases to preserve items. It is also used to dry instruments, meters and other equipment under closed conditions.
Because it can be readily separated from other substances by HPLC, silica gel is an essential component of many analytical methods. It is also often used as a drying agent for chromatography, allowing for a faster elution of the sample than would be possible with other solids such as silicic acid or activated alumina. The high specific surface area of silica gel allows it to adsorb a large number of molecules at once, and it is the most effective desiccant for small-molecule compounds.
A special type of indicating silica gel is coated with cobalt chloride, which turns from blue to purple to pink when the desiccant has reached its saturation point and should be replaced. This color-changing indicating silica gel is a useful tool for monitoring the amount of moisture that is present in the packaging of pharmaceutical products such as pills, powders, creams and lotions.
The Mw values obtained using silica gel calibration for LMWHs enoxaparin, tinzaparin and dalteparin were consistent with those obtained with conventional HP-SEC/RI or HP-SEC/RI-UV, even when employing narrow fractions or broad calibrant on both polymeric and silica gel columns. In contrast, the Pd values varied more significantly when using narrow or broad calibrant with polymeric gel columns, and were not consistent between laboratories.